Substance

ID:449198

Names and Identifiers
IUPAC name
1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[(2S)-3-methyl-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino}butanamido]-1,6-diphenylhexan-2-yl]carbamate
Synonyms
NorvirRitonavir
IUPAC Traditional name
1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[(2S)-3-methyl-2-{[methyl({[2-(propan-2-yl)-1,3-thiazol-4-yl]methyl})carbamoyl]amino}butanamido]-1,6-diphenylhexan-2-yl]carbamate
Registration numbers
CAS Number
155213-67-5
Properties
Product Information
Application(s)
Used to treat HIV infection and AIDS
Antiviral agent
Pharmacology Properties
Mechanism of Action
HIV-1 protease inhibitor
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Pat. Coop. Treaty (WIPO), 1995, Abbott, 95 07 696; CA, 122, 299083, (synth, pharmacol)
• Kempf, D.J. et al., J. Med. Chem., 1998, 41, 602-617, (rev)
• Lea, A.P. et al., Drugs, 1996, 52, 541, (rev)
• Kempf, D.J. et al., Proc. Natl. Acad. Sci. U.S.A., 1995, 92, 2484, (pharmacol)
• Leonard, J.M., Adv. Exp. Med. Biol., 1996, 394, 319, (pharmacol, rev)
• Markowitz, M. et al., J. Virol., 1995, 69, 701, (pharmacol)
• Kumar, G.N. et al., J. Pharmacol. Exp. Ther., 1996, 277, 423, (metab)
• Koudriakova, T. et al., Drug Metab. Dispos., 1998, 26, 552-561, (metab)
• Danner, S.A. et al., N. Engl. J. Med., 1995, 333, 1528; 1534, (clin trials)
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