Substance
ID:449197
Names and Identifiers
IUPAC name
3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyrimidin-4-one
Synonyms
RisperdalRisperidoneBelivonRispolin
IUPAC Traditional name
3-{2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl}-2-methyl-4H,6H,7H,8H,9H-pyrido[1,2-a]pyrimidin-4-one
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Used for the treatment of schizophrenia and bipolar disorder
Antipsychotic agent
Pharmacology Properties
Mechanism of Action
5-HT 2 and dopamine-D 2 receptor antagonist
Also adrenergic receptor activity
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
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• Peeters, O.M. et al., Acta Cryst. C, 1993, 49, 1698, (cryst struct)
• Rabasseda, X. et al., Drugs of Today (Barcelona), 1993, 29, 535, (rev)
• Edwards, J.G., Br. Med. J., 1994, 308, 1311, (rev)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 690
• Mannens, G. et al., Drug Metab. Dispos., 1993, 21, 1134, (metab, man)
• Meuldermans, W. et al., Drug Metab. Dispos., 1994, 22, 129, (metab, exp)
• Eur. Pat., 1986, Janssen, 196 132; CA, 106, 67292x, (synth, pharmacol)
• Aravagiri, M. et al., J. Pharm. Sci., 1993, 82, 447, (hplc)
• Grant, S. et al., Drugs, 1994, 48, 253, (rev)
• Livingston, M.G., Lancet, 1994, 457, (rev)
• Garcia, G. et al., Hosp. Formul., 1994, 29, 357; 363, (rev)
• Le Moing, J.P. et al., J. Chromatogr., 1993, 614, 333, (hplc)