Substance
ID:449193
Names and Identifiers
Synonyms
ReserpineSerpasilApoplonReserpoidSermixSandrilCarpacil
IUPAC name
methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyloxy)-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8-tetraene-19-carboxylate
IUPAC Traditional name
methyl (1R,15S,17R,18R,19S,20S)-6,18-dimethoxy-17-(3,4,5-trimethoxybenzoyloxy)-3,13-diazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8-tetraene-19-carboxylate
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Antiadrenergic
Antineoplastic agent
Antihypertensive agent acting by depleting stores of noradrenaline in sympathetic neurones
Anticonvulsant agent
Possesses sedative tranquilliser props.
Biological Source
Alkaloid from Rauwolfia serpentina, Rauwolfia vomitoria, Rauwolfia macrophylla , very many other Rauwolfia spp., Vinca minor, Alstonia constricta and many other spp. in the Apocynaceae,
e.g. Tenduzia longifolia, Vallesia dichotoma and Excavatia coccinea
Pharmacology Properties
Mechanism of Action
Disruption of norepinephrine, serotonin, and dopamine presynaptic vesicles by the transporter VMAT
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
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• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 343; 386
• Taylor, W.I. et al., The Vinca Alkaloids, Marcel Dekker, 1973, (rev, props)
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