Substance
ID:449189
Names and Identifiers
IUPAC name
2-(2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride
Synonyms
AccuproQuinapril HydrochlorideAccuprinAcequinAcuprilQuinazilAccuprilAccuretic
IUPAC Traditional name
2-(2-{[(2S)-1-ethoxy-1-oxo-4-phenylbutan-2-yl]amino}propanoyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid hydrochloride
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Antihypertensive agent
Salt Data
HCl
Pharmacology Properties
Mechanism of Action
Angiotensin converting enzyme inhibitor
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 10165, (synonyms)
• Frank, G.J. et al., J. Cardiovasc. Pharmacol., 1990, 15, S14, (Quinapril)
• Zagermann, P., Pharm. Ztg., 1992, 137, 35; 39, (rev)
• Plosker, G.L. et al., Drugs, 1994, 48, 227, (rev)
• Wadworth, A.N. et al., Drugs, 1991, 41, 378, (rev)
• Saynavalammi, P. et al., J. Pharmacol. Exp. Ther., 1986, 237, 246, (pharmacol)
• Materson, B.J., Am. J. Cardiol., 1992, 69, 46C, (tox)
• Hengy, H. et al., J. Liq. Chromatogr., 1988, 11, 517, (hplc)
• Kaplan, H.R. et al., Angiology, 1989, 40, 335, (tox, exp)
• Begg, E.J. et al., Br. J. Clin. Pharmacol., 1994, 37, 302, (pharmacokinet, human)
• ACE Inhibitors: Current Use and Future Prospects, (Ed. Schachter, M.), M. Dunitz, 1995, (pharmacol, use, rev)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 938
• Klutchko, S. et al., J. Med. Chem., 1986, 29, 1953, (synth, pharmacol)
• Dostal, L.A. et al., Fundam. Appl. Toxicol., 1991, 17, 684, (reprod tox)