Substance
ID:449188
Names and Identifiers
IUPAC name
(2E)-but-2-enedioic acid; bis(2-[2-(4-{2-thia-9-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-10-yl}piperazin-1-yl)ethoxy]ethan-1-ol)
Synonyms
Quetiapine FumarateSeroquelKetipinor
IUPAC Traditional name
(2E)-but-2-enedioic acid; bis(2-[2-(4-{2-thia-9-azatricyclo[9.4.0.03,8]pentadeca-1(11),3(8),4,6,9,12,14-heptaen-10-yl}piperazin-1-yl)ethoxy]ethan-1-ol)
Registration numbers
CAS Number
Properties
Pharmacology Properties
Mechanism of Action
Antagonist of dopamine and serotonin receptors
Specifically the D1 and D2 dopamine, the alpha 1 adrenoreceptor and alpha 2 adrenoreceptor, and 5-HT1A and 5-HT2 serotonin receptor
Product Information
Application(s)
Antipsychotic and neuroleptic agent
Salt Data
0.5 Fumarate
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Eur. Pat., 1987, ICI Americas, 240 228; CA, 108, 37876q, (synth, pharmacol)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 690
• Warawa, E.J. et al., J. Med. Chem., 2001, 44, 372-389, (synth, pharmacol)
• Pullen, R.H. et al., J. Chromatogr., 1992, 573, 49, (hplc, gc-ms)
• Campbell, A. et al., Psychopharmacology (Berlin), 1991, 103, 323, (pharmacol)
• Goldstein, J.M., Drugs of Today (Barcelona), 1999, 35, 193-210
• Saller, C.F. et al., Psychopharmacology (Berlin), 1993, 112, 285; 293; 299, (pharmacol)