Substance
ID:449175
Names and Identifiers
Synonyms
AnandronNilandronNilutamide
IUPAC name
5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
IUPAC Traditional name
5,5-dimethyl-3-[4-nitro-3-(trifluoromethyl)phenyl]imidazolidine-2,4-dione
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Antineoplastic agent
Used for treatment of prostatic cancer
Pharmacology Properties
Mechanism of Action
Androgen receptor blocker, preventing its interaction with testosterone
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
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• Ojasoo, T., Drugs of the Future, 1987, 12, 763, (rev)
• Ger. Pat., 1977, Roussel, 2 649 925; CA, 87, 85005, (synth)
• Decensi, A. et al., Eur. J. Cancer, 1991, 27, 1100, (clin trial)
• Pendyala, L. et al., Cancer Chemother. Pharmacol., 1988, 22, 69, (metab)
• Gomez, J.-L. et al., Am. J. Med., 1992, 92, 563, (tox)
• Raynaud, J.P. et al., Prog. Clin. Biol. Res., 1985, 185A, 99, (rev, pharmacol)
• Moguilewsky, M. et al., Prog. Cancer Res. Ther., 1988, 35, 349, (rev, activity)
• Martindale, The Extra Pharmacopoeia, 30th edn., Pharmaceutical Press, 1993, 496
• Moguilewsky, M. et al., J. Steroid Biochem., 1987, 27, 871, (rev, pharmacol)
• Dhar, J.D. et al., Contraception, 1990, 42, 121, (tox)
• Berson, A. et al., J. Pharmacol. Exp. Ther., 1994, 270, 167, (tox)