Substance
ID:449161
Names and Identifiers
Synonyms
CamptosarCamptetinCamptoTopotecinIrinotecan
IUPAC Traditional name
(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate
IUPAC name
(19S)-10,19-diethyl-19-hydroxy-14,18-dioxo-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2(11),3,5,7,9,15(20)-heptaen-7-yl 4-(piperidin-1-yl)piperidine-1-carboxylate
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Use is in colon cancer
Antineoplastic agent
Pharmacology Properties
Mechanism of Action
Topoisomerase I inhibitor
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
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• Wiseman, L.R. et al., Drugs, 1996, 52, 606, (rev)
• Kaneda, N. et al., Cancer Res., 1990, 50, 1715, (metab)
• Aiyama, R. et al., Chem. Pharm. Bull., 1992, 40, 2810, (uv, cd, bibl)
• Burris, H.A. et al., Semin. Oncol., 1992, 19, 663, (use, rev)
• Henegar, K.E. et al., J.O.C., 1997, 62, 6588-6597, (synth)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 543
• Kunimoto, T. et al., Cancer Res., 1987, 47, 5944, (pharmacol)
• Sawada, S. et al., Chem. Pharm. Bull., 1991, 39, 1446, (synth, trihydrate, pmr, uv, cmr, cryst struct, activity)
• Nitta, K. et al., Recent Adv. Chemother., Proc. Int. Congr. Chemother., 14th, 1985, 1, 28, (synth, pharmacol)
• Rivory, L.P. et al., Cancer Res., 1994, 54, 6330, (metab, human)
• Robert, J. et al., Drugs of Today (Barcelona), 1998, 34, 777-803, (rev)
• Atsumi, R. et al., Xenobiotica, 1991, 21, 1159, (metab)
• Boisseau, M. et al., Expert Opin. Invest. Drugs, 1996, 5, 613, (rev)
• Curran, D.P. et al., Angew. Chem., Int. Ed., 1995, 34, 2683, (synth)