Substance
ID:449156
Names and Identifiers
IUPAC name
3-ethyl-4-methyl-2-oxo-N-(2-{4-[({[(1r,4r)-4-methylcyclohexyl]carbamoyl}amino)sulfonyl]phenyl}ethyl)-2,5-dihydro-1H-pyrrole-1-carboxamide
Synonyms
AmarylGlimepirideEndialGlimepiridaAmarelGlimepiridGlimepiridumGlimepride
IUPAC Traditional name
3-ethyl-4-methyl-2-oxo-N-(2-{4-[({[(1r,4r)-4-methylcyclohexyl]carbamoyl}amino)sulfonyl]phenyl}ethyl)-2,5-dihydro-1H-pyrrole-1-carboxamide
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Hypoglycaemic agent
Pharmacology Properties
Mechanism of Action
Cyclooxygenase pathway inhibitor,
Potassium channel blocker
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Leclercq-Meyer, V. et al., Biochem. Pharmacol., 1991, 42, 1634, (pharmacol)
• Ozaki, Y. et al., Biochem. Pharmacol., 1992, 44, 687, (pharmacol)
• Iwata, M. et al., Acta Cryst. C, 1997, 53, 329-331, (cryst struct)
• Nguyen, C. et al., Drugs of Today (Barcelona), 1998, 34, 391-400; 401-408, (rev)
• Donaubauer, H.H. et al., Arzneim.-Forsch., 1993, 43, 547; 1068, (tox, exp)
• Mller, G. et al., Biochem. J., 1993, 289, 509, (pharmacol)
• Mller, G. et al., Biochem. Pharmacol., 1994, 48, 985, (pharmacol)
• Langtry, H.D. et al., Drugs, 1998, 55, 563-584, (rev)
• Lehr, K.H. et al., J. Chromatogr., 1990, 526, 497, (hplc)
• Weyer, R. et al., Arzneim.-Forsch., 1988, 38, 1079; 1120, (synth, pharmacol)
• Ratheiser, K. et al., Arzneim.-Forsch., 1993, 43, 856, (pharmacol, human)