Substance
ID:449153
Names and Identifiers
IUPAC name
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine
Synonyms
IressaIrressatTarcevaGefitinib
IUPAC Traditional name
N-(3-chloro-4-fluorophenyl)-7-methoxy-6-[3-(morpholin-4-yl)propoxy]quinazolin-4-amine
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Gefitinib is a drug used in the treatment of certain types of cancer
Pharmacology Properties
Mechanism of Action
It is the first selective inhibitor of epidermal growth factor receptor's (EGFR) tyrosine kinase domain
Gefitinib inhibits EGFR tyrosine kinase by binding to the adenosine triphosphate (ATP)-binding site of the enzyme.
Thus the function of the EGFR tyrosine kinase in activating the Ras signal transduction cascade is inhibited, and malignant cells are inhibited
Molecule Details
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Molecular Spectra
No Data Available
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References
• 88th Annual Meeting of the American Association for Cancer Research, San Diego, California, USA, 12 -16 April 1997. Lecture, 4251