Substance
ID:449148
Names and Identifiers
IUPAC name
2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
Synonyms
DiflucanElazorTriflucanBiozoleneFluconazoleFungata
IUPAC Traditional name
2-(2,4-difluorophenyl)-1,3-bis(1H-1,2,4-triazol-1-yl)propan-2-ol
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Antifungal agent
Effective in single oral dose against vaginal candidiasis
Not active against Aspergillus
Prophylactic treatment for AIDS patients
Pharmacology Properties
Mechanism of Action
Inhibitor of fungal cytochrome P450 enzyme 14alpha-demethylase
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Cobos Garcia, F.J. et al., Farm. Clin., 1991, 8, 423, (rev)
• U.K. Pat., 1982, Pfizer, 2 099 818; CA, 99, 38467q, (synth, pharmacol)
• Urbak, S.F. et al., Ophthalmologica, 1994, 208, 147, (use, rev)
• Pat. Coop. Treaty (WIPO), 1997, Pfizer, 97 28 169; CA, 127, 220800s, (fosfluconazole, synth, pharmacol)
• Fluconazole, (Eds., Powderly, W.G. et al), Marius Press, 1992, (book)
• Morck, H., Pharm. Ztg., 1991, 136, 56; 60, (rev)
• Morita, K. et al., Chem. Pharm. Bull., 1992, 40, 1247, (pharmacol)
• Grant, S.M. et al., Drugs, 1990, 39, 877, (rev)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 378
• Negwer, M., Organic-Chemical Drugs and their Synonyms, 7th edn., Akademie-Verlag, 1994, 3349, (synonyms)
• Goa, K.L. et al., Drugs, 1995, 50, 658, (rev, pharmacokinet)