Substance
ID:449145
Names and Identifiers
IUPAC name
(1S)-21-methyl-3,13,21-triazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,15(20),16,18-heptaen-14-one
Synonyms
Evodiamine
IUPAC Traditional name
(1S)-21-methyl-3,13,21-triazapentacyclo[11.8.0.02,10.04,9.015,20]henicosa-2(10),4,6,8,15(20),16,18-heptaen-14-one
Registration numbers
CAS Number
Properties
Product Information
Biological Source
A major component of the Chinese drug Wou-chou-yu (the dried fruit of Evodia rutaecarpa ).
Also present in Araliopsis tabouensis (Rutaceae, Araliaceae)
Application(s)
Diuretic and diaphoretic agent
Pharmacology Properties
Mechanism of Action
May interact with UCP1, which is a thermogenic protein that allows energy to be burned as heat
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Chatterjee, A. et al., Tetrahedron, 1959, 7, 257, (isol)
• Gopinath, K.W. et al., Tetrahedron, 1960, 8, 293, (isol)
• Danieli, B. et al., Heterocycles, 1978, 9, 803, (synth)
• Yamazaki, M. et al., Tet. Lett., 1966, 3221; 1967, 3317, (biosynth)
• Danieli, B. et al., Chem. Comm., 1982, 1092, (synth, cd, abs config)
• Danieli, B. et al., Experientia, 1979, 35, 156, (isol, uv, cd, ir, pmr, ms, abs config, synth, 7-Carboxyevodiamine)
• Kobayashi, Y. et al., Planta Med., 2000, 66, 526-530, (activity)
• Tams, J. et al., Acta Chim. Acad. Sci. Hung., 1976, 89, 85, (ms)
• Kametani, T. et al., J.A.C.S., 1976, 98, 6186, (synth, ir, uv, pmr, ms)
• Bergman, J. et al., J.O.C., 1985, 50, 1246, (synth)