Substance
ID:449127
Names and Identifiers
IUPAC name
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide
Synonyms
CelebrexCelecoxib
IUPAC Traditional name
4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benzene-1-sulfonamide
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Used in the treatment of rheumatoid arthritis and osteoarthritis
Non-steroidal antiinflammatory drug
Inhibits colon carcinogenesis in animal models
Also used in the treatment of familial adenomatous polyposis
Pharmacology Properties
Mechanism of Action
Cyclooxygenase-2 (COX-2) inhibitor
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Lipsky, P.E. et al., J. Rheumatol., Suppl. 49, 1997, 24, 9-14; 20-24, (use)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 25
• Hubbard, R.C. et al., J. Invest. Med., 1996, 44, 293A, (pharmacol)
• De Vleeschauwer, M. et al., Synlett, 1997, 375-377, (synth)
• Reddy, B.S. et al., Cancer Res., 1996, 56, 4566-4569; 1998, 58, 409-412, (pharmacol)
• Graul, A. et al., Drugs of the Future, 1997, 22, 711-714, (rev)
• Zhang, Y. et al., J. Pharmacol. Exp. Ther., 1997, 283, 1069-1075, (pharmacol)
• Pat. Coop. Treaty (WIPO), 1995, Searle, 95 15316; CA, 123, 340112h, (synth, pharmacol)
• Penning, T.D. et al., J. Med. Chem., 1997, 40, 1347-1365, (synth, pharmacol, pmr)
• Clemett, D. et al., Drugs, 2000, 59, 957-980, (rev)
• Kawamori, T. et al., Cancer Res., 1998, 58, 409-412, (pharmacol)