Substance
ID:449113
Names and Identifiers
IUPAC name
[(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl]methanol
Synonyms
AbacavirZiagen
IUPAC Traditional name
[(1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]cyclopent-2-en-1-yl]methanol
Registration numbers
CAS Number
Properties
Product Information
Application(s)
Antiviral agent
Shows anti-HIV activity
Pharmacology Properties
Mechanism of Action
HIV reverse transcriptase inhibitor
Molecule Details
No Data Available
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Molecular Spectra
No Data Available
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References
• Pat. Coop. Treaty (WIPO), 1996, Wellcome Foundation, 96 06 844; CA, 125, 41774y, (succinate)
• Daluge, S.M., Antimicrob. Agents Chemother., 1997, 41, 1082-1093; 1099-1107, (pharmacol, activity)
• Olivo, H.F., J.C.S. Perkin 1, 1998, 391, 392, (synth, bibl)
• Pat. Coop. Treaty (WIPO), 1998, Glaxo, 98 52 949; CA, 130, 38645e, (abacavir sulfate)
• Hervey, P.S. et al., Drugs, 2000, 60, 447-479, (rev)
• Eur. Pat., 1991, Wellcome Foundation, 434 450; CA, 115, 208462c, (synth, pharmacol)
• Martindale, The Extra Pharmacopoeia, 32nd edn., Pharmaceutical Press, 1999, 602
• Crimmins, M.T. et al., J.O.C., 1996, 61, 4192-4193, (synth, pmr, cmr, ir)
• Graul, A. et al., Drugs of the Future, 1998, 23, 1155-1167, (abacavir sulfate)
• Moyle, J.G., Curr. Opin. Infect. Dis., 2000, 13, 19
• Foster, R.H. et al., Drugs, 1998, 55, 729-736, (rev)
• Daluge, S.M. et al., Nucleosides Nucleotides, 2000, 19, 297-327, (synth)