Substance
ID:4466
Names and Identifiers
IUPAC name
(2S)-2-[(2S)-4-[(2E,4E,6R)-6-[(1S,2S,5S,6S,7S)-1,6-dimethyl-8,9-dioxaspiro[bicyclo[3.3.1]nonane-2,2'-oxiran]-3-en-7-yl]-4-methylhepta-2,4-dienoyl]-5-hydroxy-1-[(2S,5S,6S)-5-hydroxy-6-methyloxan-2-yl]-3-oxo-2,3-dihydro-1H-pyrrol-2-yl]-N-methylpropanamide
Synonyms
StreptolydiginPortamycinAntibiotic D-45
IUPAC Traditional name
streptolydigin
Properties
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Molecule Details
Drug Groups
experimental
Pharmacology
Streptolydigin is an antibiotic which works by blocking nucleic acid chain elongation by binding to the polymerase, thus stopping RNA polymerase activity inside a cell. Specifically, it inhibits the assembly of the RNA polymerase II transcription complex and DNA polymerase III transcription. It is active against a number of gram positive bacteria.
Affected Organisms
Enteric bacteria and other eubacteria
External Links
Molecular Spectra
No Data Available
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References
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