Substance
ID:4397
Names and Identifiers
Brand Name
BiligrafinBilignostCholografinBilignostumTransbilixCholospect
Synonyms
Iodipamic acidAdipiodonum [INN-Latin]Adipiodona [INN-Spanish]IDBIodipamide3,3'-[(1,6-dioxohexane-1,6-diyl)diimino]bis(2,4,6-triiodobenzoic acid)Adipiodone
IUPAC Traditional name
iodipamide
IUPAC name
3-{5-[(3-carboxy-2,4,6-triiodophenyl)carbamoyl]pentanamido}-2,4,6-triiodobenzoic acid
Properties
Physical Property
Solubility
0.46 mg/mL at 20 oC [BEILSTEIN]
Molecule Details
Drug Groups
approved
Description
Iodipamide is a water-soluble radiographic contrast media for cholecystography and intravenous cholangiography. [PubChem]
Indication
Iodipamide is used as a contrast agent for cholecystography and intravenous cholangiography.
Toxicity
Ionic radiocontrast agents like iodipamide are cytotoxic to renal cells. The toxic effects include apoptosis, cellular energy failure, disruption of calcium homeostasis, and disturbance of tubular cell polarity, and are thought to be linked to oxidative stress. Acute IV LD50 is 5000 mg/kg in rat, 3195 mg/kg in mouse, and 1200 mg/kg in dog.
Affected Organisms
Humans and other mammals
Biotransformation
Hepatic.
References
•
Lin SK, Moss AA, Riegelman S: Iodipamide kinetics: capacity-limited biliary excretion with simultaneous pseudo-first-order renal excretion. J Pharm Sci. 1977 Dec;66(12):1670-4.
[Pubmed]
Molecular Spectra
No Data Available
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References
• Lin SK, Moss AA, Riegelman S: Iodipamide kinetics: capacity-limited biliary excretion with simultaneous pseudo-first-order renal excretion. J Pharm Sci. 1977 Dec;66(12):1670-4. Pubmed