Substance
ID:436
Names and Identifiers
IUPAC name
9-methoxy-7H-furo[3,2-g]chromen-7-one
IUPAC Traditional name
methoxsalen
Synonyms
Methoxsalen
Brand Name
ZanthotoxinOxsoralen LotionProralone-MopPuvalenPuvametXanthotoxinXanthoxinUltramop LotionMethoxalenNew-MeladininOxypsoralenXanthotoxineMethoxatenMeladoxenMeloxineMethoxa-DomeOxoralenOxsoralenUltra MopAmmoidinMeladinineOxsoralen-UltraPsoralen-MopUvadexAmmodinMeladinin
Properties
Physical Property
Solubility
0.0476 mg/mL at 30 oC [YALKOWSKY,SH & DANNENFELSER,RM (1992)]
Hydrophobicity(logP)
1.7
Molecule Details
Drug Groups
approved
Description
A naturally occurring furocoumarin compound found in several species of plants, including Psoralea corylifolia. It is a photoactive substance that forms DNA adducts in the presence of ultraviolet A irradiation. [PubChem]
Indication
For the treatment of psoriasis and vitiligo
Pharmacology
Methoxsalen selectively inhibits the synthesis of deoxyribonucleic acid (DNA). The guanine and cytosine content correlates with the degree of Methoxsalen-induced cross-linking. At high concentrations of the drug, cellular RNA and protein synthesis are also suppressed.
Affected Organisms
Humans and other mammals
Half Life
Approximately 2 hours
Elimination
In both mice and man, methoxsalen is rapidly metabolized. Approximately 95% of the drug is excreted as a series of metabolites in the urine within 24 hours (Pathak et al. 1977).
External Links
Molecular Spectra
No Data Available
Click here to submit data
References
No Data Available
Click here to submit data