Substance
ID:399186
Names and Identifiers
IUPAC Traditional name
zileuton
IUPAC name
1-[1-(1-benzothiophen-2-yl)ethyl]-1-hydroxyurea
Synonyms
ZileutonZYFLOLeutrolAbbott 64077N-(1-Benzo[b]thien-2-yl-ethyl)-N-hydroxyureaA-64077
Registration numbers
CAS Number
Properties
Physical Property
Melting Point
157-158°C
Solubility
DMSO
Apperance
White Solid
Safety Information
Storage Condition
Refrigerator
MSDS Link
Product Information
Certificate of Analysis
Molecule Details
An inhibitor of 5-lipoxygenase, the initial enzyme in the biosynthesis of leukotrienes from Arachidonic Acid. Used as an antiasthmatic.
Molecular Spectra
No Data Available
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References
• Weinblatt, M.E., et al.: J. Rheumatol., 19, 1537 (1991)
• McGill, K and Busse, W.W.: Lancet, 348, 519 (1996)
• Carter, G.W., et al.: J. Pharmacol. Exp. Ther., 256, 929 (1991)