Substance
ID:399049
Names and Identifiers
IUPAC name
N-{3-[5-(4-chlorophenyl)-1H-pyrrolo[2,3-b]pyridine-3-carbonyl]-2,4-difluorophenyl}propane-1-sulfonamide
IUPAC Traditional name
vemurafenib
Synonyms
N-[3-[[5-(4-Chlorophenyl)-1H-pyrrolo[2,3-b]pyridin-3-yl]carbonyl]-2,4-difluorophenyl]-1-propanesulfonamideVemurafenibRG 7204Ro 51-85426PLX 4032
Registration numbers
CAS Number
Properties
Product Information
Certificate of Analysis
Safety Information
MSDS Link
Molecule Details
Vemurafenib selective BRAFV600E kinase inhibitor; an antitumor agent. Vemurafenib functions by inhibiting the proliferation and mitogen-activated protein/extracellular signal-regulated kinase (ERK) kinase and ERK phosphorylation in a panel of tumor cell l
Molecular Spectra
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References
• Yang, H. et al.: Cancer Res., 70, 5518 (2010)
• Comin-Anduix, B. et al.: Clin. Cancer Res., 16, 6040 (2010)
• Halaban, R. et al.: Pigm. Cell. Melonoma Res., 23, 190 (2010)