Substance
ID:399017
Names and Identifiers
IUPAC name
5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]-6H-pyrimido[1,6-b]pyridazin-6-one
IUPAC Traditional name
5-(2,6-dichlorophenyl)-2-[(2,4-difluorophenyl)sulfanyl]pyrimido[1,6-b]pyridazin-6-one
Synonyms
5-(2,6-Dichlorophenyl)-2-[(2,4-difluorophenyl)thio]-6H-pyrimido[1,6-b]pyridazin-6-oneVX 745
Registration numbers
CAS Number
Properties
Safety Information
MSDS Link
Product Information
Certificate of Analysis
Molecule Details
VX 745 is a potent and selective inhibitor of p38α mitogen-activated protein (MAP) kinase. VX 745 is a potential anti-inflammatory agents. Studies suggest that VX 745 may be useful in the treatment of Werner syndrome.
Molecular Spectra
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References
• Duffy, J.P. et al.: ACS Med. Chem. Lett., 2, 758 (2001)
• Bagley, M.C. et al.: Pharmaceuticals, 3, 1842 (2001)
• Haddad, J.J.: Curr. Opin. Invest. Drugs, 2, 1070 (2001)