Substance
ID:397157
Names and Identifiers
IUPAC name
4-{6-methoxy-7-[3-(piperidin-1-yl)propoxy]quinazolin-4-yl}-N-[4-(propan-2-yloxy)phenyl]piperazine-1-carboxamide
IUPAC Traditional name
tandutinib
Synonyms
CT 53518MLN 5184-[6-Methoxy-7-[3-(1-piperidinyl)propoxy]-4-quinazolinyl]-N-[4-(1-methylethoxy)phenyl]-1-piperazinecarboxamideTandutinib
Registration numbers
CAS Number
Properties
Product Information
Certificate of Analysis
Physical Property
Solubility
Chloroform
Apperance
White Solid
Melting Point
177-178°C
Safety Information
MSDS Link
Storage Condition
Refrigerator
Molecule Details
An oral, small-molecule inhibitor of FLT3 for the treatment of AML (acute myelogenous leukemia) and other cancer indications. The drug exhibited limited activity as a single agent in phase I and II clinical trials in patients with AML and myelodysplastic
Molecular Spectra
No Data Available
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References
• Lombardo, L., et al.: J. Med. Chem., 47, 6658 (2002)
• F
• Knight, Z., et al.: Chem. Biol., 12, 621 (2002)
• Manning, G., et al.: Science, 298, 1912 (2002)
• Baselga, J., et al.: Science, 312, 1175 (2002)
• Garber, K., et al.: Nat. Biotechnol., 24, 127 (2002)