Substance
ID:396897
Names and Identifiers
IUPAC name
3-(4-methyl-2-{[(3Z)-2-oxo-2,3-dihydro-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid
IUPAC Traditional name
3-(4-methyl-2-{[(3Z)-2-oxo-1H-indol-3-ylidene]methyl}-1H-pyrrol-3-yl)propanoic acid
Synonyms
3-[3-(2-Carboxyethyl)-4-methylpyrrol-2-methylidenyl]-2-indolinone2-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-4-methyl-1H-pyrrole-3-propanoic AcidSU 5402
Registration numbers
CAS Number
Properties
Physical Property
Melting Point
>222°C (dec.)
Apperance
Yellow-Green Solid
Solubility
DMSO
Methanol
Safety Information
Storage Condition
-20°C Freezer
MSDS Link
Product Information
Certificate of Analysis
Molecule Details
A specific FGFR (fibroblast growth factor receptor) inhibitor. An intermediate for 3-(hetero)arylmethylidene-2-indolinone derivatives as modulators of protein kinase activity for use in treating cancer.
Molecular Spectra
No Data Available
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References
• Korynevska, A., et al.: Biochem. Pharmacol., 74, 1713 (1998)
• Cronauer, M., et al.: Eur. Urol., 43, 309 (1998)
• Panek, R., et al.: J. Pharmacol. Exp. Ther., 286, 569 (1998)
• Pao, W., et al.: J. Clin. Oncol., 23, 2556 (1998)
• Li, T., et al.: Clin. Cancer R