Substance
ID:395407
Names and Identifiers
IUPAC name
1-{[4-(1,4,8,11-tetraazacyclotetradecan-1-ylmethyl)phenyl]methyl}-1,4,8,11-tetraazacyclotetradecane
IUPAC Traditional name
plerixafor
Synonyms
Plerixafor1,1'-[1,4-Phenylenebis(methylene)]bis-1,4,8,11-tetraazacyclotetradecane
Registration numbers
CAS Number
Properties
Physical Property
Solubility
Methanol
Apperance
White Solid
Melting Point
123-127°C
Safety Information
MSDS Link
Storage Condition
Refrigerator
Product Information
Certificate of Analysis
Molecule Details
Plerixafor is a hematopoietic stem cell (HSC) mobilizer that inhibits the CXCR4 chemokine receptor and blocks binding of its ligand, stromal cell-derived factor-1-α (SDF-1-α). This agent was approved on Dec. 15, 2008, as treatment in combination with gran
Molecular Spectra
No Data Available
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References
• Leone, D., et al.: J. Pharmacol. Exp. Ther., 305, 1150 (2000)
• Chigaev, A., et al.: J. Immunol. 178, 6828 (2000)
• Xie, T., et al.: Science, 290, 328 (2000)
• Kiel, M., et al.: Cell Stem Cell, 1, 204 (2000)