Substance
ID:394580
Names and Identifiers
IUPAC name
3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea
IUPAC Traditional name
3-tert-butyl-1-(2-{[4-(diethylamino)butyl]amino}-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl)urea
Synonyms
PD 173074N-[2-[[4-(Diethylamino)butyl]amino]-6-(3,5-dimethoxyphenyl)pyrido[2,3-d]pyrimidin-7-yl]-N'-(1,1-dimethylethyl)ureaPD-173074
Registration numbers
CAS Number
Properties
Physical Property
Apperance
Yellow Solid
Solubility
Chloroform
Methanol
Melting Point
98-100°C
Safety Information
MSDS Link
Storage Condition
Refrigerator
Product Information
Certificate of Analysis
Molecule Details
PD 173074 is a selective FGFR1 and FGFR3 inhibitor. PD 173074 is a compound induced a dose-dependent reduce in cell viability and an increase in apoptosis, accompanied by a decrease in extracellular signal-related kinase phosphorylation.
Molecular Spectra
No Data Available
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References
• Buchler, et al.: 9, 119 (1997)
• Keats, J., et al.: Blood, 101, 1520 (1997)
• Mohammadi, M., et al.: Science, 276, 955 (1997)
• Yagasaki, F., et al.: Cancer Res., 61, 8371 (1997)