Substance
ID:394566
Names and Identifiers
IUPAC name
3-[(dimethylamino)methyl]-N-{2-[4-(hydroxycarbamoyl)phenoxy]ethyl}-1-benzofuran-2-carboxamide
Synonyms
PCI-24781CRA 247813-[(Dimethylamino)methyl]-N-[2-[4-[(hydroxyamino)carbonyl]phenoxy]ethyl]-2-benzofurancarboxamideCRA 024781
IUPAC Traditional name
abexinostat
Registration numbers
CAS Number
Properties
Safety Information
MSDS Link
Product Information
Certificate of Analysis
Molecule Details
PCI-24781 is a novel hydroxamic acid HDAC inhibitor (histone deacetylase inhibitor). PCI-24781 exerts cytotoxicity and histone H3 alterations via caspase-8 and FADD in leukemia cells.
Molecular Spectra
No Data Available
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References
• Morales, V., et al.: Mol. Cell Biol., 20, 7230 (2000)
• Esteller, M., et al.: Carcinogenesis, 27, 1121 (2000)
• Th'ng, J., et al.: J. Biol. Chem., 280, 27809 (2000)