Substance
ID:393194
Names and Identifiers
Synonyms
NitisinoneNTBCOrfadinNitisone2-[2-Nitro-4-(trifluoromethyl)benzoyl]-1,3-cyclohexanedioneSC 0735
IUPAC name
2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione
IUPAC Traditional name
nitisone
Registration numbers
CAS Number
Properties
Safety Information
MSDS Link
Storage Condition
-20°C Freezer
Physical Property
Melting Point
129-131°C
Apperance
Light Brown Solid
Solubility
Chloroform
Ethyl Acetate
Product Information
Certificate of Analysis
Molecule Details
Nitisinone is a herbicidal triketone that inhibits 4-hydroxyphenylpyruvate dioxygenase (HPPD), an enzyme involved in plastoquinone biosynthesis in plants and in tyrosine catabolism in mammals. It is used in treatment of inherited tyrosinemia type I.
Molecular Spectra
No Data Available
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References
• Lock, E.A., et al.: J. Inherited Metab. Dis., 21, 498 (1992)
• Lindstedt, S., et al.: Lancet, 340, 813 (1992)
• Ellis, M.K., et al.: Toxicol. Appl. Pharmacol., 133, 12 (1992)