Substance
ID:389449
Names and Identifiers
IUPAC name
5-methyl-N-[4-(trifluoromethyl)phenyl]-1,2-oxazole-4-carboxamide
IUPAC Traditional name
leflunomide
Synonyms
LeflunomideLeflunomidum5-Methylisoxazole-4-[4-trifluoromethylcarboxanilide]Leflunomida5-Methyl-N-[4-(trifluoromethyl)phenyl]-4-isoxazolecarboxamide
Registration numbers
CAS Number
Properties
Safety Information
Storage Condition
-20°C Freezer
MSDS Link
Physical Property
Solubility
Dichloromethane
Ether
Methanol
Ethyl Acetate
Melting Point
153-156°C
Apperance
Off White Solid
Product Information
Certificate of Analysis
Molecule Details
An immunosuppressive. Inhibits T and B cell proliferation. Activity is attributed mainly to its metabolite, a malononitrile derivative, which is beleived to inhibit dihydroorotate dehydrogenase as well as several protein tyrosine kinases. Therapeutical
Molecular Spectra
No Data Available
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References
• Mazzucco, G., et al.: Clin. Nephrol., 70, 163 (2008)
• Vrenken, T., et al.: J. Hepatol., 49, 799 (2008)
• Davies, M., et al.: J. Med. Chem., 52, 2683 (2008)