Substance
ID:389300
Names and Identifiers
IUPAC Traditional name
4-{[3-(1,4-diazepane-1-carbonyl)-4-fluorophenyl]methyl}-2H-phthalazin-1-one
IUPAC name
4-{[3-(1,4-diazepane-1-carbonyl)-4-fluorophenyl]methyl}-1,2-dihydrophthalazin-1-one
Synonyms
KU 0058948KU00589481-[5-[(3,4-dihydro-4-oxo-1-phthalazinyl)methyl]-2-fluorobenzoyl]hexahydro-1H-1,4-diazepineKU-0058948 4-[[4-fluoro-3-[(hexahydro-1H-1,4-diazepin-1-yl)carbonyl]phenyl]methyl]-1(2H)-phthalazinone
Registration numbers
CAS Number
Properties
Safety Information
MSDS Link
Product Information
Certificate of Analysis
Molecule Details
KU-0058948 is a poly (ADP-ribose) polymerase (PARP) inhibitor. Studies show that KU-0058948 a potent agonist that activates transfected extracellular signal-regulated kinase 8 (ERK8) in cells. KU-0058948 induces cell cycle arrest and apoptosis of primary
Molecular Spectra
No Data Available
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References
• Klevernic, I.V. et al.: FEBS Lett., 583, 680 (2009)
• Gaymes, T.J. et al.: Haematologica, 94, 638 (2009)