Substance
ID:389193
Names and Identifiers
IUPAC name
1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazin-1-yl]ethan-1-one
Synonyms
NizoralKetoconazoleBrizoralKetodermKetozoralOrifungal Mrel-1-[4-[4-[[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]-1-piperazinyl]ethanoneR 41400(+/-)-Ketoconazolecis-1-Acetyl-4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy]phenyl]piperazineFungarestFungoralNizralOnofin KPanfungolKetoisdin
IUPAC Traditional name
(2R,4S)-ketoconazole
Registration numbers
CAS Number
Properties
Physical Property
Apperance
White Solid
Melting Point
144-146°C
Solubility
Chloroform
Safety Information
MSDS Link
Storage Condition
-20°C Freezer
Product Information
Certificate of Analysis
Molecule Details
Inhibits cytochrome P-450 dependent steps in the biosynthesis of steroid hormones in vivo. Antimetastatic and antineoplastic activity. Orally active 5-lipoxygenase and thromboxane synthase inhibitor.
Molecular Spectra
No Data Available
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References
• Van Wauwe, J.P. and Janssen, P.A.J., J. Med. Chem., 32, 2231 (1986)
• Lambert, A., et al.: Biochem. Pharmacol., 35, 3999 (1986)
• Nardone, P.A., et al.: . Surg. Res., 44, 425 (1986)
• Tucker, W.F.G., et al.: Br. Med. J., 293, 882 (1986)