Antibiotic for treatment of Mycobacterium tuberculosis, inhibits mycolic acid biosynthesis. Metabolized by hepatic N-acetyltransferase (NAT) and cytochrome P450 2E1 (CYP2E1) to form hepatotoxins. Selectively induces expression of CYP2E1. Reversibly inhibi
Molecular Spectra
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References
• Brewer, G.A., et al.: Anal. Profiles Drug Subs., 6, 183 (1977)
• Weber, W.W., et al.: Clin. Pharmacokinet., 4, 401 (1979)