Substance
ID:385088
Names and Identifiers
IUPAC Traditional name
brolin
IUPAC name
(Z)-3-[({2-[(diaminomethylidene)amino]-1,3-thiazol-4-yl}methyl)sulfanyl]-N'-sulfamoylpropimidamide
Synonyms
N-[(1S)-1-(Aminocarbonyl)-4-[(2-fluoro-1-iminoethyl)amino]butyl]benzamideF-Amidine
Registration numbers
CAS Number
Properties
Safety Information
MSDS Link
Product Information
Certificate of Analysis
Molecule Details
An inhibitor of Peptidyl arginine deiminase 4 (PAD4) activity with an IC50 value of 21.6 μM in an in vitro activity assay. It irreversibly inactivates (kinact/KI = 3,000 M-1min-1) PAD4 by covalently modifying an active site cysteine that is important for
Molecular Spectra
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References
• Jones, J.E. et al.: Curr. Opin. Drug Discov. Dev., 12, 616 (2009)
• Luo, Y. et al.: Biochemistry, 45, 11727 (2009)
• Knuckley, B. et al.: Biochemistry, 49, 1 (2009)
• Slack, J.L. et al.: Cell. Mol. Life Sci.,
• Hill, J.A. et al.: J. Immunol., 171, 538 (2009)