Substance
ID:383959
Names and Identifiers
IUPAC name
2-(4-{[(3,5-dimethylphenyl)carbamoyl]methyl}phenoxy)-2-methylpropanoic acid
IUPAC Traditional name
efaproxiral
Synonyms
Efaproxiral2-[4-[2-[(3,5-Dimethylphenyl)amino]-2-oxoethyl]phenoxy]-2-methylpropanoic AcidRSR 13
Registration numbers
CAS Number
Properties
Physical Property
Apperance
Off-White to Tan Solid
Solubility
Methanol
DMSO
Melting Point
48-50°C
Safety Information
MSDS Link
Storage Condition
Refrigerator
Product Information
Certificate of Analysis
Molecule Details
Allosteric modifier of hemoglobin (HB). Binds in the central water cavity of the Hb molecule causing a conformational change such that bound oxygen is released more readily. Antineoplastic adjunct (radiosensitizer).
Molecular Spectra
No Data Available
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References
• Abraham, D.J., et al.: Biochemistry, 31, 9141 (1992)
• Pagel, P.S., et al.: J. Pharmacol. Exp. Ther., 285, 1 (1992)
• Kleinberg, L., et al.: J. Clin. Oncol., 17, 2593 (1992)