Substance
ID:382656
Names and Identifiers
Synonyms
Dibenzazepine (Deshydroxy LY 411575)N-[(1S)-2-[[(7S)-6,7-Dihydro-5-methyl-6-oxo-5H-dibenz[b,d]azepin-7-yl]amino]-1-methyl-2-oxoethyl]-3,5-difluorobenzeneacetamide
IUPAC name
(2S)-2-[2-(3,5-difluorophenyl)acetamido]-N-[(10S)-8-methyl-9-oxo-8-azatricyclo[9.4.0.02,7]pentadeca-1(11),2(7),3,5,12,14-hexaen-10-yl]propanamide
IUPAC Traditional name
(2S)-2-[2-(3,5-difluorophenyl)acetamido]-N-[(10S)-8-methyl-9-oxo-8-azatricyclo[9.4.0.02,7]pentadeca-1(11),2(7),3,5,12,14-hexaen-10-yl]propanamide
Registration numbers
CAS Number
Properties
Safety Information
Storage Condition
-20°C Freezer
MSDS Link
Physical Property
Solubility
Methanol
Chloroform
Melting Point
257-259°C
Apperance
White Solid
Product Information
Certificate of Analysis
Molecule Details
A dipeptidic γ-secretase inhibitor. AntiAlzheimer agent.
Molecular Spectra
No Data Available
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References
• Weihofen, A., et al.: J. Biol. Chem., 278, 16528 (2002)
• Krawitz, P., et al.: J. Biol. Chem., 280, 39515 (2002)
• Weihofen, A., et al.: Science, 296, 2215 (2002)
• Kan, T., et al.: Bioorg. Med. Chem. Lett., 14, 1983 (2002)
• Tomita, T., et al.: Curr. Pharm.