Substance
ID:380523
Names and Identifiers
IUPAC name
7-nitro-2,3-dioxo-1,2,3,4-tetrahydroquinoxaline-6-carbonitrile
Synonyms
6-Cyano-7-nitroquinoxaline-2,3-dioneCNQX1,2,3,4-Tetrahydro-7-nitro-2,3-dioxo-6-quinoxalinecarbonitrile6-Cyano-2,3-dihydroxy-7-nitroquinoxaline
IUPAC Traditional name
CNQX
Registration numbers
CAS Number
Properties
Safety Information
MSDS Link
Storage Condition
Refrigerator
Physical Property
Apperance
Pale Yellow Solid
Solubility
Dilute Aqueous Base
DMSO
Melting Point
>300°C
Product Information
Certificate of Analysis
Molecule Details
A potent, competitive kainate/quisqualate (non-NMDA) receptor antagonist. IC50 of tritiated ligands to rat cortical membranes by CNQX: AMPA, Kainate and CPP are 0.3mM, 1.5mM, and 25mM, respectively.
Molecular Spectra
No Data Available
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References
• Kobayashi, K., et al.: J. Pharmacol. Sci., 108, 517 (1988)
• Shabat-Simon, M., et al.: J. Neurosci., 28, 8406 (1988)
• Honore, et al. Science, 241, 701 (1988)
• Cruz, L.A., et al.: J. Med. Chem., 51, 5856 (
• Haas, H.S., et al.: Int. J. Oncol., 27, 867 (1988)