Substance
ID:380201
Names and Identifiers
IUPAC Traditional name
colchicine
IUPAC name
N-[(10S)-3,4,5,14-tetramethoxy-13-oxotricyclo[9.5.0.02,7]hexadeca-1(16),2(7),3,5,11,14-hexaen-10-yl]acetamide
Synonyms
Condylon(S)-Colchicine >95%N-[(7S)-5,6,7,9-Tetrahydro-1,2,3,10-tetramethoxy-9-oxobenzo[a]heptalen-7-yl]acetamideColchisolColsaloidColchineosColcinNSC 757(-)-Colchicine
Registration numbers
CAS Number
Properties
Product Information
Certificate of Analysis
Physical Property
Melting Point
150-152°C
Apperance
Yellow Solid
Solubility
Methanol
Ethyl Acetate
Chloroform
Safety Information
MSDS Link
Storage Condition
-20°C Freezer
Molecule Details
An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pa
Molecular Spectra
No Data Available
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References
• Jordan, A., et al.: Med. Res. Rev
• Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992)
• Andreu, J.M., et al.: Biochemistry, 37, 8356 (1992)
• Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1992)
• Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1992)