Substance
ID:379612
Names and Identifiers
IUPAC name
2-chloro-5-nitro-N-phenylbenzamide
IUPAC Traditional name
2-chloro-5-nitrobenzanilide
Synonyms
2-Chloro-5-nitro-N-4-phenylbenzamideGW9662
Registration numbers
CAS Number
Properties
Product Information
Certificate of Analysis
Safety Information
MSDS Link
Physical Property
Solubility
DMSO
Apperance
Off-White Solid
Molecule Details
A cell-permeable, selective and irreversible PPARγ antagonist (IC50 = 3.3 nM, 32 nM, and 2 μM for PPARγ, PPARα, and PPARδ, respectively). Reported to covalently modify a cysteine residue in the binding site of PPAR. At a concentration of 10 μM, also acts as an agonist of human pregnane X receptor (PXR) and farnesoid X receptor (FXR). Does not activate liver X receptor-a (LXRa), retinoic acid receptor (RAR), retinoid X receptor-a (RXRa) and thyroid receptors a and b (TRa and TRb)
Molecular Spectra
No Data Available
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References
• Leesnitzer, L.M., et al.: Biochemistry, 41, 6640 (2002)
• Huang, J.T., et al.: Nature, 400, 378 (1999)
• Wilson, T.M., et al.: J. Med. Chem., 43, 527 (1999)