Substance
ID:378376
Names and Identifiers
IUPAC Traditional name
camptothecin
Synonyms
(S)-4-Ethyl-4-hydroxy-1H-pyrano[3’,4’:6,7]indolizino[1,2-b]quinoline-3,14(4H,12H)-dione(S)-(+)-Camptothecin
IUPAC name
(19S)-19-ethyl-19-hydroxy-17-oxa-3,13-diazapentacyclo[11.8.0.02,11.04,9.015,20]henicosa-1(21),2,4,6,8,10,15(20)-heptaene-14,18-dione
Registration numbers
CAS Number
Properties
Physical Property
Solubility
Acetonitrile
DMSO
Methanol
Apperance
Pale Yellow Solid
Melting Point
239-245°C (dec.)
Safety Information
Storage Condition
-20°C Freezer
MSDS Link
Product Information
Certificate of Analysis
Molecule Details
Antitumor alkaloid. Binds irreversible to the DNA-topoisomerase I complex, inhibiting the reassociation of DNA after cleavage by topoisomerase I and traps the enzyme in a covalent linkage with DNA. A cytotoxic antitumor agent.
Molecular Spectra
No Data Available
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References
• Kaufmann, S.H., et al.: Biochim. Biophys. Acta, 1400, 195 (1994)
• Desai, S.D., et al.: J. Biol. Chem., 272, 24159 (1994)
• Fan, Y., et al.: J. Med. Chem., 41, 2216 (1994)
• Potmesil, M., et al.: Cancer Res., 54, 1431 (1994)