Substance
ID:377161
Names and Identifiers
IUPAC Traditional name
brefeldin A
IUPAC name
(1R,6S,11aS,13S,14aR)-1,13-dihydroxy-6-methyl-1H,4H,6H,7H,8H,9H,11aH,12H,13H,14H,14aH-cyclopenta[f]oxacyclotridecan-4-one
Synonyms
Brefeldin ANSC 244390NSC 89671NectrolideNSC 56310Synergisidinγ-4-Dihdyroxy-2-(6-hydroxy-1-heptenyl)-4-cyclopentanecrotonic Acid, λ-Lactone, BFA, Cyanein, Ascotoxin, Decumbin
Registration numbers
CAS Number
Properties
Product Information
Certificate of Analysis
Safety Information
Storage Condition
-20°C Freezer
MSDS Link
Physical Property
Melting Point
206-208°C
Apperance
White Solid
Solubility
Methanol
Molecule Details
A macrolide isolated from Penicillium brefeldianum. It affects the vesticular transport of the Golgi apparatus and induces DNA fragmentation which leads to apoptosis.
Molecular Spectra
No Data Available
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References
• Mordente, J.A., et al.: J. Urol., 159, 275 (1986)
• Nojiri, H., et al.: FEBS Letters, 453, 140 (1986)
• Misumi, Y., et al.: J. Biol. Chem., 261 (1986)
• Erokhina, M.V., et al.: Membr. Cell Biol., 12, 871 (1986)