Substance
ID:377151
Names and Identifiers
Synonyms
BosentanRo 47-0203Ro 47-0203/0394-(1,1-Dimethylethyl)-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)[2,2’-bipyrimidin]-4-yl]benzenesulfonamidep-tert-Butyl-N-[6-(2-hydroxyethoxy)-5-(o-methoxyphenoxy)-2-(2-pyrimidinyl)-4-pyrimidinyl]benzenesulfonamideTracleerActelion
IUPAC Traditional name
bosentan
IUPAC name
4-tert-butyl-N-[6-(2-hydroxyethoxy)-5-(2-methoxyphenoxy)-2-(pyrimidin-2-yl)pyrimidin-4-yl]benzene-1-sulfonamide
Registration numbers
CAS Number
Properties
Product Information
Certificate of Analysis
Physical Property
Solubility
Methanol
DMSO
Apperance
Pale Yellow to Off-White Solid
Melting Point
107-110°C
Safety Information
Storage Condition
-20°C Freezer
MSDS Link
Molecule Details
A mixed endothelin receptor antagonist. Used as a vasodilator. Antihypertensive.
Molecular Spectra
No Data Available
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References
• Gutsch, G., et al.: Cardiovasc. Drugs Ther., 10, 717 (1994)
• Krum, H., et al.: N. Engl. J. Med., 338, 784 (1998)
• Clozel, M., et al.: J. Pharmacol. Exp. Ther., 270, 228 (1994)
• Weber, C., et al.: Clin Pharmacol. Ther., 60, 124 (1994)