Substance
ID:376830
Names and Identifiers
IUPAC name
(3aS)-3a-hydroxy-6-methyl-1-phenyl-1H,2H,3H,3aH,4H-pyrrolo[2,3-b]quinolin-4-one
IUPAC Traditional name
(S)-blebbistatin
Synonyms
(-)-1-Phenyl-1,2,3,4-tetrahydro-4-hydroxypyrrolo[2,3-b]-7-methylquinolin-4-one(-)-Blebbistatin(3aS)-1,2,3,3a-Tetrahydro-3a-hydroxy-6-methyl-1-phenyl-4H-pyrrolo[2,3-b]quinolin-4-one(S)-(-)-Blebbistatin
Registration numbers
CAS Number
Properties
Physical Property
Solubility
Ethyl Acetate
Methanol
Chloroform
DMSO
Dichloromethane
Melting Point
>205°C (dec.)
Apperance
Bright Yellow Solid
Safety Information
MSDS Link
Storage Condition
-20°C Freezer
Product Information
Certificate of Analysis
Molecule Details
Blebbistatin blocked myosin II-dependent cell processes. It blocks cell blebbing rapidly and reversibly. Blebbistatin also rapidly disrupted directed cell migration and cytokinesis in vertebrate cell. Blebbistatin blocks both blebbing and cytokinesis
Molecular Spectra
No Data Available
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References
• Kovacs, M., et al.: J. Biol. Chem., 279, 34 35557 (2004)
• Straight, A.F., et al.: Science, 299, 1743 (2003)
• Duxbury, M.S., et al.: Biochem. Biophys. Res. Commun., 313, 992 (2003)