Substance
ID:376676
Names and Identifiers
IUPAC name
3-[1-(3-aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-2,5-dihydro-1H-pyrrole-2,5-dione
IUPAC Traditional name
3-[1-(3-aminopropyl)indol-3-yl]-4-(1-methylindol-3-yl)-1H-pyrrole-2,5-dione
Synonyms
Ro 31-75493-[1-(3-Aminopropyl)-1H-indol-3-yl]-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dioneRo 31-7549/001Bisindolylmaleimide VIII
Registration numbers
CAS Number
Properties
Safety Information
MSDS Link
Product Information
Certificate of Analysis
Molecule Details
It is a potent inhibitor of protein kinase C (PKC) activity. Bisindolylmaleimide VIII (Bis VIII) has been previously shown to enhance Fas-mediated apoptosis through a protein kinase C-independent mechanism.
Molecular Spectra
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References
• Emery, J., et al.: J. Biol. Chem., 273, 14363 (1998)
• Wiley, S., et al.: Immunity, 3, 673 (1998)
• MacFarlane, M., et al.: Biochem. J., 348, 93 (1998)