Substance
ID:374784
Names and Identifiers
Synonyms
EmendAprepitant5-[[(2R,3S)-2-[(1R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)-4-morpholinyl]methyl]-1,2-dihydro-3H-1,2,4-triazol-3-oneMK 0869ONO 7436MK 869L 754030
IUPAC name
3-{[(2R,3S)-2-[(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy]-3-(4-fluorophenyl)morpholin-4-yl]methyl}-4,5-dihydro-1H-1,2,4-triazol-5-one
IUPAC Traditional name
aprepitant
Registration numbers
CAS Number
Properties
Physical Property
Melting Point
244-246°C
Apperance
White to Off-White Solid
Solubility
Chloroform
Methanol
Product Information
Certificate of Analysis
Safety Information
MSDS Link
Storage Condition
-20°C Freezer
Molecule Details
A novel selective neurokinin-1 (NK-1) receptor antagonist. In vitro studies using human liver microsomes indicate that Aprepitant is metabolised primarily by CYP3A4 with minor metabolism by CYP1A2 and CYP2C19, and no metabolism by CYP2D6, CYP2C9, or CYP2E
Molecular Spectra
No Data Available
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References
• Hale, J.J., et al.: J. Med. Chem., 41, 4607 (1998)
• Majumdar, A.K., et al.: J. Clin. Pharmacol., 46, 291 (1998)
• Campos, D., et al.: J. Clin. Oncol., 19, 1759 (1998)
• Van Belle, S., et al.: Cancer, 94, 3032 (1998)