Substance
ID:372900
Names and Identifiers
IUPAC name
(2R)-N-hydroxy-N'-[(2S)-1-[(2S)-2-(hydroxymethyl)pyrrolidin-1-yl]-3-methyl-1-oxobutan-2-yl]-2-pentylbutanediamide
IUPAC Traditional name
actinonin
Synonyms
Ro 06-1467ActinoninCONA 57(2R)-N4-Hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-butanediamide(-)-Actinonin3-[[1-[[2-(Hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]carbamoyl]octanohydroxamic AcidActinonine
Registration numbers
CAS Number
Properties
Physical Property
Melting Point
137-139°C
Apperance
Off-White Solid
Solubility
Methanol
DMSO
Product Information
Certificate of Analysis
Safety Information
MSDS Link
Molecule Details
(-)-Actinonin is a bioactive peptide and antibiotic that is a potent inhibitor of aminopeptidase M and leucine aminopeptidase. Actinonin has observed to be an inhibitor of peptide deformylase, meprin A, and thermolysin. Actinonin also inhibits tumor cell
Molecular Spectra
No Data Available
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References
• Umezawa, H., et al.: J. Antibiot., 38, 1629 (1985)
• Escobar-Alvarez, S., et al.: J. Mol. Biol., 387, 1211 (1985)
• Berg, A., et al.: Biochem., 48, 1584 (1985)
• Kuehlmann, U., et al.: Life Sci., 84, 1 (1985)