Substance
ID:372163
Names and Identifiers
IUPAC name
2-[(2R)-2-methylpyrrolidin-2-yl]-1H-1,3-benzodiazole-7-carboxamide
IUPAC Traditional name
2-[(2R)-2-methylpyrrolidin-2-yl]-3H-1,3-benzodiazole-4-carboxamide
Synonyms
A 8616952-[(2R)-2-Methyl-2-pyrrolidinyl]-1H-benzimidazole-7-carboxamideABT 888
Registration numbers
CAS Number
Properties
Physical Property
Melting Point
194-196°C
Apperance
White Solid
Solubility
Methanol
DMSO
Safety Information
MSDS Link
Product Information
Certificate of Analysis
Molecule Details
ABT-888 is a potent, orally bioavailable PARP-1/-2 inhibitor shown to potentiate DNA damaging agents. The ability to potentiate temozolomide (TMZ) and develop a biological marker for PARP inhibition was evaluated in vivo.
Molecular Spectra
No Data Available
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References
• Tentori, L., et al.: Clin. Cancer Res., 9, 5370 (2002)
• Tentori, L., et al.: Pharmacol. Res., 52, 25 (2002)
• Kim, M., et al.: Cell, 119, 803 (2002)
• Virag, L., et al.: Pharmacol. Rev., 54, 375 (2002)