Substance
ID:372161
Names and Identifiers
IUPAC name
4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1-yl)-N-(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzenesulfonyl)benzamide
IUPAC Traditional name
4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1-yl)-N-(4-{[(2R)-4-(dimethylamino)-1-(phenylsulfanyl)butan-2-yl]amino}-3-nitrobenzenesulfonyl)benzamide
Synonyms
4-[4-[(4’-Chloro[1,1’-biphenyl]-2-yl)methyl]-1-piperazinyl]-N-[[4-[[(1R)-3-(dimethylamino)-1-[(phenylthio)methyl]propyl]amino]-3-nitrophenyl]sulfonyl]benzamideABT 737
Registration numbers
CAS Number
Properties
Physical Property
Melting Point
152-154°C
Solubility
Methanol
DMSO
Apperance
Yellow Solid
Safety Information
MSDS Link
Storage Condition
-20°C Freezer
Product Information
Certificate of Analysis
Molecule Details
A selective inhibitor of BCL-2, in small cell lung cancer. ABT-737 induced dramatic regressions in tumors derived from some SCLC cell lines.
Molecular Spectra
No Data Available
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References
• Trudel, S., et al.: Clin. Cancer Res., 13, 621 (2007)
• Ikegaki, N., et al.: Cancer Res., 54, 6 (1994)
• Kaiser, U., et al.: Lung Cancer, 15, 31 (1994)
• Rudin, C., et al.: J. Clin. Oncol., 22, 1110 ( 2004), Konopleva, M., et al.: Cancer Cell, 10, 375 (1994)