Substance
ID:371806
Names and Identifiers
IUPAC name
3-[dimethyl({3-[(4R)-4-[(1S,2S,5R,9R,10R,11S,14R,15R,16S)-5,9,16-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadecan-14-yl]pentanamido]propyl})azaniumyl]propane-1-sulfonate
IUPAC Traditional name
3-[dimethyl({3-[(4R)-4-[(1S,2S,5R,9R,10R,11S,14R,15R,16S)-5,9,16-trihydroxy-2,15-dimethyltetracyclo[8.7.0.02,7.011,15]heptadecan-14-yl]pentanamido]propyl})ammonio]propane-1-sulfonate
Synonyms
3-[(3-Cholamidopropyl)dimethylammonio]-1-propanesulfonate3-[(3-胆酰胺丙基)二甲氨基]丙磺酸内盐CHAPSCHAPS
Properties
Physical Property
Critical Micelle Concentration
6 mM(20-25°C)
Transition Temperature
cloud point >100 °C
Aggregation Number of Micelle
10
Safety Information
Risk Statements
36/37/38
German water hazard class
3
GHS Hazard statements
H315-H319-H335
GHS Precautionary statements
P261-P305+P351+P338
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
GHS Signal Word
Warning
European Hazard Symbols
Irritant (Xi)Safety Statements
26
Product Information
Empirical Formula (Hill Notation)
C32H58N2O7S
Purity
≥97.0%
Mol. Weight
micellar avg mol wt 6150
Molecule Details
Application
CHAPS is a nondenaturing zwitterionic detergent for membrane biochemistry.Useful for solubilizing membrane proteins and breaking protein-protein interactions. CHAPS’ small micellar molecular weight (6,150) and high critical micelle concentration (6-10 mM) allow it to be removed from samples by dialysis. It is also suitable for protein solubilization for isoelectric focusing and two-dimensional electrophoresis. CHAPS is commonly used for non-denaturing (without urea) IEF and has been shown to give excellent resolution of some subcellular preparations and plant proteins. Concentrations between 2-4% (w/v) are typically used in an IEF gel.
Suitability
for biological purposes
CHAPS is a nondenaturing zwitterionic detergent for membrane biochemistry.Useful for solubilizing membrane proteins and breaking protein-protein interactions. CHAPS’ small micellar molecular weight (6,150) and high critical micelle concentration (6-10 mM) allow it to be removed from samples by dialysis. It is also suitable for protein solubilization for isoelectric focusing and two-dimensional electrophoresis. CHAPS is commonly used for non-denaturing (without urea) IEF and has been shown to give excellent resolution of some subcellular preparations and plant proteins. Concentrations between 2-4% (w/v) are typically used in an IEF gel.
Suitability
for biological purposes
Molecular Spectra
No Data Available
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References
No Data Available
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