Substance
ID:366219
Names and Identifiers
Synonyms
对-[(2,4-二氨基喋啶-6)-N-甲基甲氨基]苯甲酰谷氨酸 水合物氟安定 水合物L-氨甲喋呤 水合物氨甲喋呤 水合物MTX 水合物氨甲叶酸 水合物甲氨蝶呤 水合物Methotrexate hydrateL-Amethopterin hydrateMTX hydrate4-Amino-10-methylfolic acid hydrateL-4-Amino-N10-methylpteroylglutamic acid hydrateAntifolan hydrateMethylaminopterin hydrate
IUPAC Traditional name
hydrate methotrexate
IUPAC name
(2S)-2-[(4-{[(2,4-diaminopteridin-6-yl)methyl](methyl)amino}phenyl)formamido]pentanedioic acid hydrate
Properties
Safety Information
MSDS Link
GHS Pictograms
Acute toxicity (oral, dermal, inhalation), categories 1,2,3
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
European Hazard Symbols
Toxic (T)RID/ADR
UN 1544 6.1/PG 3
Hazard Class
6.1
Safety Statements
53-26-36-45
Packing Group
3
GHS Signal Word
Danger
RTECS
MA1225000
German water hazard class
3
Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Risk Statements
46-61-25-36/38
GHS Hazard statements
H301-H315-H319-H340-H360
GHS Precautionary statements
P201-P301+P310-P305+P351+P338-P308+P313
UN Number
1544
Product Information
Empirical Formula (Hill Notation)
C20H22N8O5 · xH2O
Purity
85%
Molecule Details
Application
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.4
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also effective in treatment of pyrimethamine-resistant Plasmodium vivax malaria parasites.4
Potent inhibitor of dihydrofolate reductase1 and agent for antitumor studies.2,3 Use to inhibit dihydrofolate reductase in DHFR-based protein expression systems. Also shows immunosuppressive effects in, e.g., rheumatoid arthritis.
Molecular Spectra
No Data Available
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References
No Data Available
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