Substance
ID:365275
Names and Identifiers
IUPAC Traditional name
aebsf hydrochloride
IUPAC name
4-(2-aminoethyl)benzene-1-sulfonyl fluoride hydrochloride
Synonyms
AEBSF4-(2-氨乙基)苯磺酰氟 盐酸盐Pefabloc® SC4-(2-Aminoethyl)benzenesulfonyl fluoride hydrochloride
Registration numbers
MDL Number
Beilstein Number
CAS Number
PubChem SID
Properties
Safety Information
GHS Pictograms
Corrosive to metals, category 1
Skin corrosion, categories 1A,1B,1C
Serious eye damage, category 1
GHS Signal Word
Danger
RID/ADR
UN 3261 8/PG 2
GHS Hazard statements
H314
Safety Statements
26-36/37/39-45
MSDS Link
Risk Statements
34
Packing Group
2
German water hazard class
3
European Hazard Symbols
Corrosive (C)UN Number
3261
Personal Protective Equipment
Eyeshields, Faceshields, full-face particle respirator type N100 (US), Gloves, respirator cartridge type N100 (US), type P1 (EN143) respirator filter, type P3 (EN 143) respirator cartridges
Hazard Class
8
GHS Precautionary statements
P280-P305+P351+P338-P310
Storage Temperature
2-8°C
Product Information
Purity
≥98.0% (HPLC)
Empirical Formula (Hill Notation)
C8H10FNO2S · HCl
Grade
analytical standard
Physical Property
Melting Point
~183 °C
Molecule Details
Application
Recommended concentrations for use are 0.1-1 mM.
Biochem/physiol Actions
Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25 mM.
Other Notes
Potent and irreversible inhibitor of serine proteases; in contrast to PMSF, it is water soluble and non-toxic1,2; Unaffected by albumin3
Legal Information
Pefabloc is a registered trademark of Pentapharm
Recommended concentrations for use are 0.1-1 mM.
Biochem/physiol Actions
Irreversible serine protease inhibitor. Inhibition constants are similar to those of PMSF and DFP. AEBSF has been shown to inhibit trypsin, chymotrypsin, plasmin kallikrein and thrombin. As an alternative to PMSF and DFP, AEBSF offers lower toxicity, improved solubility in water and improved stability in aqueous solutions. AEBSF has been used in cell culture in concentrations of up to 0.25 mM.
Other Notes
Potent and irreversible inhibitor of serine proteases; in contrast to PMSF, it is water soluble and non-toxic1,2; Unaffected by albumin3
Legal Information
Pefabloc is a registered trademark of Pentapharm
Molecular Spectra
No Data Available
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References
No Data Available
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