Substance
ID:363325
Names and Identifiers
Synonyms
Bestatin hydrochlorideN-[(2S,3R)-3-Amino-2-hydroxy-4-phenylbutyryl]-L-leucine hydrochloride
IUPAC Traditional name
ubenimex hydrochloride
IUPAC name
(2S)-2-[(2S,3R)-3-amino-2-hydroxy-4-phenylbutanamido]-4-methylpentanoic acid hydrochloride
Properties
Safety Information
Storage Temperature
-20°C
Personal Protective Equipment
Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter
MSDS Link
German water hazard class
3
Product Information
Empirical Formula (Hill Notation)
C16H24N2O4 · HCl
Purity
≥99.0% (HPLC)
Physical Property
Melting Point
216-218 °C
Solubility
H2O: soluble25 mg/mL, clear, colorless
Molecule Details
Other Notes
Specific inhibitor of aminopeptidase B and leucine aminopeptidase2; Immunomodifier3; other biological effects see4
Biochem/physiol Actions
A metalloprotease inhibitor selective for aminopeptidase. Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase. It inhibits aminopeptidase B at 60 nM (using arginine-β-naphthylamide as substrate) and leucine aminopeptidase at 20 nM (leucine-β-naphthylamide as substrate). It showed no inhibition of aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, or themolysin. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation.1
Specific inhibitor of aminopeptidase B and leucine aminopeptidase2; Immunomodifier3; other biological effects see4
Biochem/physiol Actions
A metalloprotease inhibitor selective for aminopeptidase. Bestatin is a competitive and specific inhibitor of leucine aminopeptidase, aminopeptidase B, and triamino peptidase. It inhibits aminopeptidase B at 60 nM (using arginine-β-naphthylamide as substrate) and leucine aminopeptidase at 20 nM (leucine-β-naphthylamide as substrate). It showed no inhibition of aminopeptidase A, trypsin, chymotrypsin, elastase, papain, pepsin, or themolysin. It offers promise as a novel analgesic because it protects endogenous opioid peptides against degradation.1
Molecular Spectra
No Data Available
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References
No Data Available
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