Substance
ID:362591
Names and Identifiers
Synonyms
9-Methoxyfuro[3,2-g][1]benzopyran-7-oneXanthotoxinAmmoidinMethoxsalen8-MOP9-甲氧基呋喃并[3,2-g][1]苯并吡喃-7-酮甲氧沙林8-甲氧基补骨脂素花椒毒内酯8-Methoxypsoralen花椒毒素
IUPAC name
9-methoxy-7H-furo[3,2-g]chromen-7-one
IUPAC Traditional name
methoxsalen
Registration numbers
EC Number
Beilstein Number
CAS Number
MDL Number
Properties
Safety Information
GHS Hazard statements
H302-H334
German water hazard class
3
GHS Pictograms
Respiratory sensitization, category 1
Germ cell mutagenicity, categories 1A,1B,2
Carcinogenicity, categories 1A,1B,2
Reproductive toxicity, categories 1A,1B,2
Specific Target Organ Toxicity – Single exposure, categories 1,2
Specific Target Organ Toxicity – Repeated exposure, categories 1,2
Aspiration Hazard, category 1
Acute toxicity (oral, dermal, inhalation), category 4
Skin irritation, category 2
Eye irritation, category 2
Skin sensitisation, category 1
Specific Target Organ Toxicity – Single exposure, category 3
European Hazard Symbols
Harmful (Xn)RTECS
LV1400000
Risk Statements
22-43
MSDS Link
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Faceshields, Gloves
GHS Signal Word
Danger
GHS Precautionary statements
P261-P342+P311
Safety Statements
36/37
Physical Property
Melting Point
142-148 °C
148-150 °C(lit.)
Product Information
Purity
≥99.0% (HPLC)
Grade
for fluorescence
Empirical Formula (Hill Notation)
C12H8O4
Loss on Drying
≤1% loss on drying
Molecule Details
Biochem/physiol Actions
8-methoxypsoralen (8-MOP) plus ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms. Cultured normal human melanocytes treated with 8-methoxypsoralen and irradiated with ultraviolet A (UVA) formed 8-methoxypsoralen-phospholipid photoadducts that could be substituted for diacylglycerol to activate protein kinase C in a cell-free system. 8-MOP is an inactivator of purified reconstituted cytochrome P450. It also inhibits substance P-induced histamine release from substance P-activated rat peritoneal mast cells by suppressing the rise in [Ca2+].
Other Notes
Properties1; Photochemical reactions of 8-methoxypsoralen with calf thymus DNA2
8-methoxypsoralen (8-MOP) plus ultraviolet A (UVA) irradiation induces monoadducts and interstrand cross-links in DNA and therefore can be used to study DNA repair and recombination mechanisms. Cultured normal human melanocytes treated with 8-methoxypsoralen and irradiated with ultraviolet A (UVA) formed 8-methoxypsoralen-phospholipid photoadducts that could be substituted for diacylglycerol to activate protein kinase C in a cell-free system. 8-MOP is an inactivator of purified reconstituted cytochrome P450. It also inhibits substance P-induced histamine release from substance P-activated rat peritoneal mast cells by suppressing the rise in [Ca2+].
Other Notes
Properties1; Photochemical reactions of 8-methoxypsoralen with calf thymus DNA2
Molecular Spectra
No Data Available
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References
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