General description This certified reference material (CRM) is produced and certified in accordance with ISO/IEC 17025 and ISO Guide 34. Other Notes Values of analytes vary lot to lot. Biochem/physiol Actions Doxycycline hyclate inhibits the inflammatory response to the Lyme Disease Spirochete Borrelia burgdorferi1. It is a broad spectrum inhibitor of matrix metalloproteinases in vivo.